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KMID : 0613820060160071181
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Journal of Life Science
2006 Volume.16 No. 7 p.1181 ~ p.1187
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Antiinflammatory Effects of New Chemical Compounds, HS-1580 Series(HS-1580, HS-1581, HS-1582)
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Kim Ji-Young
Kim Kyun-Ha
Suh Hong-Suk
Choi Won-Chul
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Abstract
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HS-1580 series (HS-1580, HS-1581, HS-1582) can produce anti-imflammatory effects were synthesized from the marine algae extraction in 2,3,6-tribromo-4,5-dihydroxy benzyl methyl ether (TDB). Raw 264.7 cells were pre-treated with 1 μg/μl lipopolysaccharide (LPS) and later treated with HS-1580 series. These cells of inflammatory mediators were tested as well. Nitric oxide (NO) is related to autoimmune disease and is produced by inducible NOS (iNOS). When treated with HS-1580 series, the product of NO will reduce in a dose-dependent manner. HS-1580 series significantly inhibit the iNOS protein expression. Cyclooxygenase (COX) involves with the various physiologic events and catalyzes in prostaglandin. HS-1580 series also inhibit the COX-2 protein expression as well as pro-inflammatory cytokines production such as tumor necrosis factor-α (TNF-α) and interluekin-1β (IL-1β). These upcoming results suggest that HS-1580 series have anti-inflammatory effects in Raw 264.7 cells by inhibiting such as iNOS, COX-2, TNF-α and IL-1β as inflammatory mediators.
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KEYWORD
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Raw 264.7, NO, COX-2, inflammation, HS-1580, HS-1581, HS-1582, TNF-α
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